干扰素调节因子2重组兔单抗
Rrmab®兔单抗
货号：bsm-52115R
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概述
产品编号
bsm-52115R
产品类型
重组兔单抗
英文名称
IRF2 Recombinant Rabbit mAb
中文名称
干扰素调节因子2重组兔单抗
英文别名
IRF-2; 9830146E22Rik; IRF2_HUMAN; IRF2; IRF2_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IRF2: 300-349
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5F2
理论分子量
39 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse | 1:500-2000 |
| IHC-P | Human, Mouse | 1:50-200 | |
| IHC-F | Human, Mouse | 1:50-200 | |
| IF | Human, Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
IRF2
蛋白名
Interferon regulatory factor 2
亚细胞定位
Nucleus.
组织特异性
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
翻译后修饰
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation by SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
相似性
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
功能
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
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