Histone H2A.Z Rabbit pAb (一抗) - WB | Bioss
货号：bs-8154R
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概述
产品编号
bs-8154R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
Histone H2A.Z Rabbit pAb
中文名称
组蛋白H2AZ抗体
英文别名
H2A.Z-1; H2A.z; H2A/z; H2AFZ; H2AZ; H2A.Z1; H2AZ_HUMAN; H2AZ1; H2AZ_MOUSE; H2AZ_RAT; H2A.Z variant histone 1; H2A histone family, member Z; H2A histone family member Z
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Histone H2A.Z: 71-128/128
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
13 kDa
检测分子量
15 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Cow, Chicken, Dog | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Cow, Chicken, Dog)
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靶标
基因名
H2AZ1
蛋白名
Histone H2A.Z
亚基
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.
亚细胞定位
Nucleus. Chromosome.
翻译后修饰
Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).
Not phosphorylated.
Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).
Not phosphorylated.
相似性
Belongs to the histone H2A family.
功能
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
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