human CD18 Mouse mAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt | Bioss

2026-03-02~2026-04-30,KXJ26032026-03-02~2026-04-30,促销赠品
human CD18 Mouse mAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt | Bioss
货号:bsm-30018M
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概述

产品编号
bsm-30018M
产品类型
流式抗体
英文名称
human CD18 Mouse mAb
中文名称
小鼠抗人CD18单克隆抗体
英文别名
CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7; ITB2_HUMAN; ITGB2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta;
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human CD18
亚型
Mouse IgG1, k
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
18F7
理论分子量
82 kDa
检测分子量
90-95 kDa
浓度
1mg/ml
储存液
0.01M PBS (pH7.4).
SWISS
Gene ID
保存条件
Store at 2-8℃. Protect from light. Avoid freezing.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
LFA-1主要与除红细胞、血小板之外的人外周血各类白细胞反应,与骨髓、胸腺、扁桃体细胞、某些肿瘤细胞反应和表达。又称白细胞黏附蛋白。
背景资料
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
小鼠抗人CD18单克隆抗体-bsm-30018M小鼠抗人CD18单克隆抗体-bsm-30018M小鼠抗人CD18单克隆抗体-bsm-30018M

产品应用

应用已检合格种属预测种属推荐稀释比例
IHC-PHuman1:100-500
IHC-FHuman1:100-500
IFHuman1:100-500
Flow-CytHuman1:50-100

交叉反应

交叉反应: Human

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靶标

基因名
ITGB2
蛋白名
Integrin beta-2
亚基
Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR. Interacts with COPS5 and RANBP9.
亚细胞定位
Membrane; Single-pass type I membrane protein.
翻译后修饰
Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.
疾病
Leukocyte adhesion deficiency 1 (LAD1) [MIM:116920]: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the integrin beta chain family.
Contains 1 VWFA domain.
功能
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.

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