ACP5 Rabbit pAb (一抗) | Bioss
货号：bs-6434R
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概述
产品编号
bs-6434R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
ACP5 Rabbit pAb
中文名称
抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
英文别名
HPAP; TRACP5a; TRACP5b; TRAP; TRAcP; TrATPase; PPA5_HUMAN; ACP5; TR-AP; Tartrate-resistant acid ATPase (TrATPase); Type 5 acid phosphatase; 3.1.3.2;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human TRAP/Tartrate Resistant Acid Phosphatase: 101-200/325
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
34 kDa
检测分子量
35 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
抗酒石酸盐酸性磷酸酶(Tartrate-Resistant Acid Phosphatase,TRAP)是破骨细胞功能的重要标志物,它的活性与破骨细胞活性呈正相关.
背景资料
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | Rat, Rabbit, Pig, Dog, Horse | 1:500-2000 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Dog, Horse | 1ug/Test |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Dog, Horse)
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靶标
基因名
ACP5
蛋白名
Tartrate-resistant acid phosphatase type 5
亚基
Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).
亚细胞定位
Lysosome.
疾病
Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.
相似性
Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
功能
Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.
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