The kinesin family of motor proteins comprise at least two forms of conventional kinesin (kinesin-I). They are encoded by different genes and designated ubiquitous kinesin, which is expressed in all cells and tissues, and neuronal kinesin, which is expressed exclusively in neuronal cells. Conventional kinesin is a heterotetramer of two kinesin heavy chain subunits and two kinesin light chain subunits. While the kinesin heavy chain contains motor activity, evidence suggests that the kinesin light chain is involved in either modulation of kinesin heavy chain activity or in cargo binding. The motor protein kinesin is a heterotetramer composed of two heavy chains and two light chains. Kinesin motor activity is dependent on the presence of ATP and microtubules.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
Rabbit, Sheep, Cow, Chicken, Horse
1:500-2000
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Sheep, Cow, Chicken, Horse)
相关产品
暂无相关产品
靶标
基因名
KLC1
蛋白名
Kinesin light chain 1
亚基
Belongs to the kinesin light chain family.
Contains 6 TPR repeats.
亚细胞定位
Cytoplasm; cytoskeleton.
组织特异性
Found in a variety of tissues. Mostly abundant in brain and spine.
翻译后修饰
Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.
相似性
Belongs to the kinesin light chain family. Contains 6 TPR repeats.
功能
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.