IRE1 Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号：bs-8680R
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概述
产品编号
bs-8680R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
IRE1 Rabbit pAb
中文名称
内质网核信号转导蛋白a1抗体
英文别名
IRE1-BETA; IRE1b; IRE2p; hIRE2p; Ern1; Ire1; mIre1; ERN1_HUMAN; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1 (hIRE1p); Ire1-alpha (IRE1a); ERN1_MOUSE; Inositol-requiring protein 1;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human IRE1a: 252-260/977
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
105 kDa
检测分子量
135 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
ERN2, endoplasmic reticulum to nucleus signaling 2, induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. It is pro-apoptotic and appears to play no role in the unfolded-protein response, unlike closely related proteins.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 | |
| IHC-F | Human, Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 | |
| IF | Human, Mouse, Rat | Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Cow, Dog, Horse)
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靶标
基因名
ERN1
蛋白名
Serine/threonine-protein kinase/endoribonuclease IRE1
亚基
Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2.
亚细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
组织特异性
Ubiquitously expressed. High levels observed in pancreatic tissue.
翻译后修饰
Autophosphorylated.
相似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain.
Contains 1 KEN domain.
Contains 1 protein kinase domain.
功能
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
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