CES1/Liver Carboxylesterase 1 Rabbit pAb (一抗) | Bioss

2026-05-01~2026-06-30,AB2605
CES1/Liver Carboxylesterase 1 Rabbit pAb (一抗) | Bioss
货号:bs-18301R
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概述

产品编号
bs-18301R
产品类型
农牧业/家禽抗体
英文名称
CES1/Liver Carboxylesterase 1 Rabbit pAb
中文名称
肝羧酸酯酶1抗体
英文别名
ACAT; CE-1; CEH; CES2; HMSE; HMSE1; PCE-1; REH; SES1; TGH; hCE-1; Ces-1; Ces1; Ses-1; Es1; Es2; Es22; EST1_HUMAN; Acyl-coenzyme A:cholesterol acyltransferase (ACAT); Brain carboxylesterase hBr1; Carboxylesterase 1 (CE-1 | hCE-1); Cholesteryl ester hydrolase (CEH); Cocaine carboxylesterase; Egasyn; Methylumbelliferyl-acetate deacetylase 1; Monocyte/macrophage serine esterase; Retinyl ester hydrolase (REH); Serine esterase 1; Triacylglycerol hydrolase (TGH); EST1_MOUSE; Acyl-coenzyme A:cholesterol acyltransferase; Carboxylesterase 1G; ES-x; 3.1.1.1; Ces1g; EST1C_RAT; Ces1c; Carboxyesterase ES-1 (E1); ES-THET; Esterase-2; Liver carboxylesterase 1; Neutral retinyl ester hydrolase (NREH); EST1E_RAT; Ces1e; Carboxyesterase ES-3; ES-HTEL; Liver carboxylesterase 3; pI 5.5 esterase; carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); human monocyte/macrophage serine esterase 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CES1: 151-250/567
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
61 kDa
检测分子量
66 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
肝羧酸酯酶1抗体-bs-18301R肝羧酸酯酶1抗体-bs-18301R肝羧酸酯酶1抗体-bs-18301R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouseHuman, Rat, Rabbit, Pig, Cow1:500-2000
IHC-PRatHuman, Mouse, Rabbit, Pig, Cow1:100-500
IHC-FRatHuman, Mouse, Rabbit, Pig, Cow1:100-500
IFRatHuman, Mouse, Rabbit, Pig, Cow1:100-500

交叉反应

交叉反应: Mouse, Rat (predicted: Human, Rabbit, Pig, Cow)

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靶标

基因名
Ces1
蛋白名
Liver carboxylesterase 1
亚细胞定位
Endoplasmic reticulum lumen.
组织特异性
Expressed predominantly in liver with lower levels in heart and lung.
翻译后修饰
Contains sialic acid.
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
相似性
Belongs to the type-B carboxylesterase/lipase family.
功能
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

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