NSMase2 Rabbit pAb (一抗) - IHC-P,IHC-F,IF,ELISA | Bioss

bs-11193R

宠物抗体、农牧业/家禽抗体

NSMase2 Rabbit pAb

中性鞘磷脂2抗体

NSMASE2; NSMA2_HUMAN; SMPD3; Neutral sphingomyelinase 2 (nSMase-2 | nSMase2); Neutral sphingomyelinase II; 3.1.4.12; sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

Rabbit

KLH conjugated synthetic peptide derived from human NSMase2: 511-610/655

IgG

Liquid

affinity purified by Protein A

Polyclonal

71 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

N-SMase2 (neutral sphingomyelinase 2), also known as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), is a ubiquitously expressed 655 amino acid member of the magnesium-dependent phosphohydrolase protein family. Localized to the membrane of the Golgi apparatus, N-SMase2 functions to catalyze the hydrolysis of sphingomyelin to form ceramide and phosphocholine—two proteins that mediate cell growth arrest and apoptosis. N-SMase2 is enzymatically activated by unsaturated fatty acids and phosphatidylserine and, through regulation of ceramide synthesis, is involved in growth suppression and postnatal development. Expression of N-SMase2 is upregulated during the G0/G1 phases of the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of 7.5. N-SMase2 deficiency is the cause of chondrodysplasia, a genetic disorder characterized by impaired bone growth that leads to short stature, bowlegs and underdeveloped joints.