ATP1A1 Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号：bs-9570R
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概述
产品编号
bs-9570R
产品类型
mIHC精品抗体
英文名称
ATP1A1 Rabbit pAb
中文名称
Na+/K+-ATPase α1 钠钾ATP酶α1抗体
英文别名
CMT2DD; HOMGSMR2; Atpa-1; Nkaa1b; AT1A1_HUMAN; ATP1A1; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1; 7.2.2.13; AT1A1_MOUSE; AT1A1_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human ATP1A1: 901-1023/1023 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
112 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
通道蛋白（Channel Protein）
钠钾ATP酶是位于细胞膜上的一种糖蛋白,与ATP 的分解和细胞内外钠、钾离子的转运密切相关,哺乳动物各种组织细胞的钠钾ATP 酶的免疫学特性基本相同。
背景资料
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May2009].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ATP1A1
蛋白名
Sodium/potassium-transporting ATPase subunit alpha-1
亚基
nteracts with SIK1. Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1.
亚细胞定位
Cell membrane; Multi-pass membrane protein. Melanosome.
组织特异性
Found in most tissues.
翻译后修饰
Phosphorylation on Tyr-10 modulates pumping activity. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity.
相似性
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
功能
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
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