MYPT1 Rabbit pAb (一抗) | Bioss

bs-23290R

宠物抗体、农牧业/家禽抗体

MYPT1 Rabbit pAb

肌球蛋白磷酸酶抗体

GUBS; M130; MBS; MYPT1; 1200015F06Rik; 5730577I22Rik; D10Ertd625e; M110; MBSP; MYPT1_HUMAN; PPP1R12A; Myosin phosphatase-targeting subunit 1 (Myosin phosphatase target subunit 1); Protein phosphatase myosin-binding subunit; MYPT1_MOUSE; MYPT1_RAT; Protein phosphatase subunit 1M (PP-1M); Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110;

Rabbit

KLH conjugated synthetic peptide derived from human MYPT1: 311-410/1030

IgG

Liquid

affinity purified by Protein A

Polyclonal

113 kDa

113 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in non muscle cells. The guanosine triphosphate (GTP) bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho associated kinase (Rho kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Therefore Rho appears to inhibit myosin phosphatase through the action of Rho kinase.