整合素α2(CD49b)重组兔单抗

Rrmab®兔单抗
2026-01-04~2026-02-28,RR26012026-01-04~2026-02-28,TR
整合素α2(CD49b)重组兔单抗
货号:bsm-52613R
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概述

产品编号
bsm-52613R
产品类型
重组兔单抗
英文名称
Integrin alpha 2 Recombinant Rabbit mAb
中文名称
整合素α2(CD49b)重组兔单抗
英文别名
BR; CD49B; FMAIT3; GPIa; HPA-5; VLA-2; VLAA2; DX5; ITA2_HUMAN; ITGA2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia (GPIa); VLA-2 subunit alpha; ITA2_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Integrin alpha 2: 1100-1181
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
14D7
理论分子量
127 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to act upstream of or within cell adhesion. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗整合素α2(CD49b)重组兔单抗

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500
ICC/IFHumanMouse, Rat1:50-200

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
ITGA2
蛋白名
Integrin alpha-2
亚基
Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.
亚细胞定位
Membrane; Single-pass type I membrane protein.
相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.
功能
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

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