SIP1 Rabbit pAb (一抗) | Bioss

bs-20484R

宠物抗体、农牧业/家禽抗体

SIP1 Rabbit pAb

Smad蛋白相互作用蛋白1抗体

HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B; 9130203F04Rik; D130016B08Rik; Zfx1b; Zfxh1b; ZEB2_HUMAN; ZEB2; Smad-interacting protein 1 (SMADIP1); Zinc finger homeobox protein 1b; KIAA0569; ZEB2_MOUSE; Smad-interacting protein 1;

Rabbit

KLH conjugated synthetic peptide derived from human SIP1: 1061-1160/1214

IgG

Liquid

affinity purified by Protein A

Polyclonal

136 kDa

133 kDa

1mg/ml

Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.