MYL3 Rabbit pAb (一抗) | Bioss
货号：bs-2240R
产品详情
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常见问题
概述
产品编号
bs-2240R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
MYL3 Rabbit pAb
中文名称
肌球蛋白轻链3抗体
英文别名
CMH8; MLC-lV/sb; MLC1SB; MLC1V; VLC1; VLCl; MLC1s; Mylc; MLClV; Mylc1v; rVMLC1; MYL3_HUMAN; MYL3; Cardiac myosin light chain 1 (CMLC1); Myosin light chain 1, slow-twitch muscle B/ventricular isoform (MLC1SB); Ventricular myosin alkali light chain; Ventricular myosin light chain 1 (VLCl); Ventricular/slow twitch myosin alkali light chain (MLC-lV/sb); MYL3_MOUSE; Myosin alkali light chain 1, ventricular/slow skeletal muscle isoform; MYL3_RAT; Myosin alkali light chain 1, ventricular (MLClV); Ventricular myosin light chain 1 (rVMLC1); myosin light chain 3; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow; myosin, light chain 3, alkali
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human MLC/Myosin light chain 3: 101-195/195
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
22 kDa
检测分子量
25 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains each ~200,000 daltons, and four light chains each ~16,000 - 21,000 daltons. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. Human myosin light chain has clinical application as a cardiac marker.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human, Rabbit, Pig, Cow, Chicken, Dog | 1:500-2000 |
| IHC-P | Mouse | Human, Rat, Rabbit, Pig, Cow, Chicken, Dog | 1:100-500 |
| IHC-F | Mouse | Human, Rat, Rabbit, Pig, Cow, Chicken, Dog | 1:100-500 |
| IF | Mouse | Human, Rat, Rabbit, Pig, Cow, Chicken, Dog | 1:100-500 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Pig, Cow, Chicken, Dog)
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靶标
基因名
MYL3
蛋白名
Myosin light chain 3
亚基
Myosin is a hexamer of 2 heavy chains and 4 light chains.
翻译后修饰
The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.
N-terminus is methylated by METTL11A/NTM1.
疾病
Cardiomyopathy, familial hypertrophic 8 (CMH8)[MIM:608751]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Contains 3 EF-hand domains.
功能
Regulatory light chain of myosin. Does not bind calcium.
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