Sodium hydrogen exchanger 1 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

2026-05-01~2026-06-30,AB2605
Sodium hydrogen exchanger 1 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号:bs-0505R
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概述

产品编号
bs-0505R
产品类型
宠物抗体、农牧业/家禽抗体、离子通道抗体
英文名称
Sodium hydrogen exchanger 1 Rabbit pAb
中文名称
钠氢通道蛋白抗体
英文别名
APNH; LIKNS; NHE-1; NHE1; PPP1R143; Mir5122; mir-5122; swe; SL9A1_HUMAN; SLC9A1; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1 (NHE-1); Solute carrier family 9 member 1; APNH1; SL9A1_MOUSE; SL9A1_RAT; solute carrier family 9 member A1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; protein phosphatase 1, regulatory subunit 143; Sodium/hydrogen exchanger 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human NHE1: 470-550/815 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
91 kDa
检测分子量
91 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
通道蛋白(Channel Protein)
钠-氢交换蛋白(NHE: Na+/H+ Exchanger)是维持细胞内环境的主要细胞膜蛋白质之一,它的一个主要功能是调节细胞内pH值,使之保持在生理范围之内。细胞内pH值的变化,直接或间接的影响细胞的生长分裂、增殖和分化,也影响细胞的死亡。
钠-氢交换蛋白质的活性还影响细胞的移动和肿瘤细胞的转移。
目前主要方向是:研究消化道肿瘤细胞转移。
背景资料
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]
钠氢通道蛋白抗体-bs-0505R钠氢通道蛋白抗体-bs-0505R

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, RatMouse, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse1:500-2000
IHC-PMouseHuman, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse1:100-500
IHC-FMouseHuman, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse1:100-500
IFMouseHuman, Rat, Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse1:100-500

交叉反应

交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse)

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靶标

基因名
SLC9A1
蛋白名
Sodium/hydrogen exchanger 1
亚基
Oligomer. Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminus domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Kidney and intestine.
翻译后修饰
O-glycosylated.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1.
相似性
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
功能
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

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