FOXP1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
概述
Hox程序的信息输出并有调节运动神经元功能。FoxP1在Hox敏感型运动柱中表达，使FoxP1失活能消除运动神经元Hox网络的信息输出，并将脊髓运动系统回复到原始状。
FoxP1的减少同样改变运动神经元连结性模式， 肢体运动神经似乎会随机选择目标肌肉和作用路径。单个的FoxP1转录因子能以Hox辅助因子的形式整合各种神经元种类的连结性。
Hox蛋白：哺乳动物的同源盒基因由61个氨基酸残基组成的蛋白质保守结构域,称同源异型域。Hox基因在动物体的体节结构分化等空间信息调控中起着重要作用,按特异的空间模式赋予每一体节其自身的特点。Hox基因不但影响胚胎发育，在生殖过程中也起着重要的调节作用.
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Contains 1 fork-head DNA-binding domain.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse | 1:500-2000 |
| IHC-P | Human, Mouse | 1:50-200 | |
| IHC-F | Human, Mouse | 1:50-200 | |
| IF | Human, Mouse | 1:50-200 | |
| Flow-Cyt | Human, Mouse | 1:50-100 | |
| ICC/IF | Human, Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Mouse
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