叉头蛋白P1重组兔单抗

bsm-52078R

重组兔单抗

FOXP1 Recombinant Rabbit mAb

叉头蛋白P1重组兔单抗

12CC4; HSPC215; MFH; QRF1; hFKH1B; 3110052D19Rik; 4932443N09Rik; FOXP1_HUMAN; FOXP1; Mac-1-regulated forkhead (MFH); FOXP1_MOUSE; Forkhead-related transcription factor 1; FOXP1_RAT;

Rabbit

A synthesized peptide derived from human FOXP1: 350-401/677

IgG

Liquid

affinity purified by Protein A

Recombinant

15E2

79 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Hox程序的信息输出并有调节运动神经元功能。FoxP1在Hox敏感型运动柱中表达，使FoxP1失活能消除运动神经元Hox网络的信息输出，并将脊髓运动系统回复到原始状。
FoxP1的减少同样改变运动神经元连结性模式， 肢体运动神经似乎会随机选择目标肌肉和作用路径。单个的FoxP1转录因子能以Hox辅助因子的形式整合各种神经元种类的连结性。
Hox蛋白：哺乳动物的同源盒基因由61个氨基酸残基组成的蛋白质保守结构域,称同源异型域。Hox基因在动物体的体节结构分化等空间信息调控中起着重要作用,按特异的空间模式赋予每一体节其自身的特点。Hox基因不但影响胚胎发育，在生殖过程中也起着重要的调节作用.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]