细胞角蛋白9重组兔单抗
Rrmab®兔单抗
货号：bsm-52066R
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概述
产品编号
bsm-52066R
产品类型
重组兔单抗
英文名称
Cytokeratin 9 Recombinant Rabbit mAb
中文名称
细胞角蛋白9重组兔单抗
英文别名
K1C9_HUMAN; KRT9; Cytokeratin-9 (CK-9); Keratin-9 (K9);
抗体来源
Rabbit
免疫原
Recombinant human Cytokeratin 9 protein (300-450aa)
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
4F8
理论分子量
62 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Rat | Human, Mouse | 1:500-1000 |
| IHC-P | Human, Rat, Mouse | 1:50-200 | |
| IHC-F | Human, Rat, Mouse | 1:50-200 | |
| IF | Human, Rat, Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse)
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靶标
基因名
KRT9
蛋白名
Keratin, type I cytoskeletal 9
组织特异性
Expressed in the terminally differentiated epidermis of palms and soles.
疾病
Defects in KRT9 are a cause of palmoplantar keratoderma epidermolytic (EPPK) [MIM:144200]; also abbreviated as EHPPK. EPPK is a dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins. Some patients may present with knuckle pads, thick pads of skin appearing over the proximal phalangeal joints.
相似性
Belongs to the intermediate filament family.
功能
May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.
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