Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse, Rat
Human, Rabbit, Sheep, Cow, Dog, Horse
1:500-2000
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Sheep, Cow, Dog, Horse)
相关产品
暂无相关产品
靶标
基因名
LCLAT1
蛋白名
Lysocardiolipin acyltransferase 1
亚细胞定位
Endoplasmic reticulum membrane.
组织特异性
Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.
相似性
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.