CK20 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-52060R

重组兔单抗、病理级抗体、mIHC精品抗体

CK20 Recombinant Rabbit mAb

细胞角蛋白20重组兔单抗

CD20; CK-20; CK20; K20; KRT21; 9030623C06Rik; K1C20_HUMAN; KRT20; Cytokeratin-20 (CK-20); Keratin-20 (K20); Protein IT; K1C20_MOUSE; K1C20_RAT; Cytokeratin-21 (CK-21); keratin 20; keratin 20, type I

Rabbit

A synthesized peptide derived from human Cytokeratin 20: 400-424

IgG

Liquid

affinity purified by Protein A

Recombinant

1F10

48 kDa

45 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

结构蛋白（Structural Proteins）
CK-20细胞角蛋白-20主要用于肿瘤方面的研究，近年来大多用于消化系统恶性肿瘤的鉴别，主要在胞浆。

Cytokeratin 20 is a type I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Their genes are clustered in a region of chromosome 17q12-q21. Cytokeratin 20 is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. It is also expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system and is present in mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas lack cytokeratin 20.

KRT20

Keratin, type I cytoskeletal 20

Heterotetramer of two type I and two type II keratins. Associates with KRT8.

Cytoplasm.

Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.

Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.

Belongs to the intermediate filament family.

Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).