周期素D3兔单克隆抗体

bsm-52047R

重组兔单抗

Cyclin D3 Recombinant Rabbit mAb

周期素D3兔单克隆抗体

9230106B05Rik; CCND3_BOVIN; CCND3; CCND3_HUMAN; CCND3_MOUSE; Cyl-3; CCND3_RAT;

Rabbit

Recombinant human Cyclin D3 protein, around C-terminal 200aa

IgG

Liquid

affinity purified by Protein A

Recombinant

4A8

32 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞周期素是周期素依赖激酶的调节因子，不同的细胞周期素控制着细胞周期中不同的特定阶段。
周期素D3与周期素D1和D2一样，为细胞周期中G1期进入S期的一个重要调控因子，通过激活CdK4或CdK6等作用，促进DNA合成，加速细胞增殖，主要用于B细胞淋巴瘤、乳腺癌、头颈部鳞癌、食道癌、肝癌和肺癌等恶性肿瘤的研究。

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].