This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human, Rat, Sheep, Cow, Horse
1:500-2000
Flow-Cyt
Mouse
Human, Rat, Sheep, Cow, Horse
1μg/Test
交叉反应
交叉反应: Mouse (predicted: Human, Rat, Sheep, Cow, Horse)
相关产品
暂无相关产品
靶标
基因名
PCDH12
蛋白名
Protocadherin-12
亚细胞定位
Cell membrane. Cell junction.
组织特异性
Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression. Prominent expression in the spleen.
相似性
Contains 6 cadherin domains.
功能
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.