CCR3 Rabbit pAb (一抗) | Bioss

bs-23671R

CCR3 Rabbit pAb

细胞表面趋化因子受体3抗体

C C CKR3; CC-CKR-3; CD193; CKR 3; CKR3; CMKBR3; CC-CKR3; Cmkbr1l2; CCR3_HUMAN; CCR3; C-C CKR-3; CCR-3; Eosinophil eotaxin receptor; CCR3_MOUSE; Macrophage inflammatory protein 1-alpha receptor-like 2 (MIP-1 alpha RL2); CCR3_RAT; C-C motif chemokine receptor 3; chemokine (C-C motif) receptor 3

Rabbit

KLH conjugated synthetic peptide derived from mouse CCR3: 131-230/355 <Extracellular>

IgG

Liquid

affinity purified by Protein A

Polyclonal

41 kDa

59 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

趋化因子受体3(CCR3)主要在嗜酸粒细胞，Th2淋巴细胞，肥大细胞，支气管上皮细胞上表达， CCR3介导嗜酸粒细胞内有丝分裂原活化蛋白激酶（MAPK） 细胞外信号调节激酶-2（ERK2）、p38和JNK的活化。

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3(CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.