Smad2 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss

bsm-52223R

重组兔单抗、KO/KD Validated

Smad2 Recombinant Rabbit mAb

细胞信号转导分子Smad-2重组兔单抗

CHTD8; JV18; JV18-1; LDS6; MADH2; MADR2; hMAD-2; hSMAD2; 7120426M23Rik; Smad-2; mMad2; SMAD2_HUMAN; SMAD2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2 (hMAD-2); SMAD family member 2 (SMAD 2 | Smad2 | hSMAD2); SMAD2_MOUSE; Mad-related protein 2 (mMad2); SMAD family member 2 (SMAD 2 | Smad2); SMAD2_RAT; Mad-related protein 2;

Rabbit

A synthesized peptide derived from human SMAD2: 230-270

IgG

Liquid

affinity purified by Protein A

Recombinant

9A3

52 kDa

60 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

转录调节因子（Transcriptin Regulators）

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]