FBXO21 Rabbit pAb (一抗) | Bioss

bs-9121R

宠物抗体、农牧业/家禽抗体

FBXO21 Rabbit pAb

F-box蛋白21抗体

FBX21_HUMAN; FBXO21; FBX21; KIAA0875; FBX21_MOUSE;

Rabbit

KLH conjugated synthetic peptide derived from human FBXO21: 65-170/628

IgG

Liquid

affinity purified by Protein A

Polyclonal

72 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.