SQSTM1/P62 Mouse mAb (一抗) - WB,ELISA | Bioss
货号：bsm-51287M
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概述
产品编号
bsm-51287M
英文名称
SQSTM1/P62 Mouse mAb
中文名称
SQSTM1/P62单克隆抗体
英文别名
A170; DMRV; EBIAP; FTDALS3; NADGP; OSIL; PDB3; ZIP3; p60; p62; p62B; OSF-6; Osi; STAP; STONE14; ZIP; SQSTM_HUMAN; SQSTM1; EBI3-associated protein of 60 kDa (EBIAP | p60); Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62 (p62); ORCA; SQSTM_MOUSE; Ubiquitin-binding protein p62; SQSTM_RAT; Protein kinase C-zeta-interacting protein (PKC-zeta-interacting protein);
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human SQSTM1/P62
亚型
IgG1
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
6C5
理论分子量
60 kDa
检测分子量
62 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cell Death > Autophagy > Autophagosome
Cardiovascular > Heart > Autophagy > Autophagosome
Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription
Metabolism > Pathways and Processes > Metabolism processes > Autophagy and mitophagy > Autophagosome
Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation
Signal Transduction > Signaling Pathway > Nuclear Signaling > NFkB Pathway
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| ELISA | Human | 1:5000-10000 |
交叉反应
交叉反应: Human
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靶标
基因名
SQSTM1
蛋白名
Sequestosome-1
亚基
Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum.
亚细胞定位
Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
组织特异性
Ubiquitously expressed.
翻译后修饰
Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.
疾病
Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.
相似性
Contains 1 OPR domain.
Contains 1 UBA domain.
Contains 1 UBA domain.
功能
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
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