SMAD9 Rabbit pAb (一抗) | Bioss
货号：bs-4253R
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概述
产品编号
bs-4253R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
SMAD9 Rabbit pAb
中文名称
SMAD家族9抗体
英文别名
SMAD9_HUMAN; SMAD9; MAD homolog 9; Mothers against DPP homolog 9; Madh6; SMAD family member 9 (SMAD 9 | Smad9); MADH9; SMAD8; SMAD9_MOUSE; Madh8; SMAD9_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human SMAD9: 361-467/467
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
52 kDa
检测分子量
50 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
SMAD9 is a member of the MAD-related family of molecules. MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Pig, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Pig, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Pig, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Pig, Cow, Chicken, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Pig, Cow, Chicken, Dog, Horse | 3μg/Test |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Cow, Chicken, Dog, Horse)
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靶标
基因名
SMAD9
蛋白名
Mothers against decapentaplegic homolog 9
亚基
Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit.
亚细胞定位
Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).
组织特异性
Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
翻译后修饰
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
疾病
Defects in SMAD9 may be a cause of primary pulmonary hypertension (PPH1) [MIM:178600]. A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
相似性
Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.
功能
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
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