DNase gamma Rabbit pAb (一抗) | Bioss
货号：bs-24731R
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概述
产品编号
bs-24731R
英文名称
DNase gamma Rabbit pAb
中文名称
脱氧核糖核酸酶γ抗体
英文别名
D3; DHP2; DNAS1L3; LSD; SLEB16; DNasegamma; DNSL3_HUMAN; DNASE1L3; DNase gamma; DNase I homolog protein DHP2; Deoxyribonuclease I-like 3 (DNase I-like 3); Liver and spleen DNase (LS-DNase | LSD); 3.1.21.-; DNSL3_MOUSE; DNSL3_RAT; DNaseY;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human DNase gamma: 71-170/305
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
36 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Mouse | 1:400-800 |
| IHC-F | Rat | Human, Mouse | 1:400-800 |
| IF | Rat | Human, Mouse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse)
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靶标
基因名
DNASE1L3
蛋白名
Deoxyribonuclease gamma
亚细胞定位
Nucleus.
组织特异性
Liver and spleen.
疾病
Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16) [MIM:614420]. A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
相似性
Belongs to the DNase I family.
功能
Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.
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