周期素E重组兔单抗

bsm-52048R

重组兔单抗

Cyclin E1 Recombinant Rabbit mAb

周期素E重组兔单抗

CCNE; pCCNE1; CycE1; CYCLE; CCNE1_HUMAN; CCNE1; CCNE1_MOUSE; CCNE1_RAT;

Rabbit

A synthesized peptide derived from human Cyclin E1: 350-410

IgG

Liquid

affinity purified by Protein A

Recombinant

4H7

45 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞周期素E是调控细胞G-1→S期转变的关键因素。由于在多种肿瘤中的不适当表达,细胞周期素E现在已明确为原癌基因。

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.