eIF4A3 Rabbit pAb (一抗) | Bioss
货号：bs-14548R
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常见问题
概述
产品编号
bs-14548R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
eIF4A3 Rabbit pAb
中文名称
eIF4A3蛋白抗体
英文别名
IF4A3_CHICK; EIF4A3; eIF-4A-III; eIF4A-III; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3; 3.6.4.13; DDX48; IF4A3_BOVIN; IF4A3_MACFA; IF4A3_HUMAN; Eukaryotic initiation factor 4A-like NUK-34; Nuclear matrix protein 265 (NMP 265 | hNMP 265); KIAA0111; IF4A3_MOUSE; IF4A3_RAT; I4A3B_XENLA; eif4a3-b; XeIF-4AIII; eIF-4A-III-B; eIF4A-III-B; ATP-dependent RNA helicase DDX48-B; ATP-dependent RNA helicase eIF4A-3-B; DEAD box protein 48-B; Eukaryotic translation initiation factor 4A isoform 3-B; I4A3A_XENLA; eif4a3-a; eIF-4A-III-A; eIF4A-III-A; ATP-dependent RNA helicase DDX48-A; ATP-dependent RNA helicase eIF4A-3-A; DEAD box protein 48-A; Eukaryotic translation initiation factor 4A isoform 3 A; ddx48-a; IF4A3_DANRE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human eIF4A3: 351-411/411
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
47 kDa
检测分子量
47 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Human, Mouse, Rat | Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Human, Mouse, Rat | Cow, Chicken, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 2ug/Test |
| ICC/IF | Human | Mouse, Rat, Cow, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Cow, Chicken, Dog, Horse)
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靶标
基因名
EIF4A3
蛋白名
Eukaryotic initiation factor 4A-III
亚细胞定位
Nucleus. Nucleus speckle. Cytoplasm. Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites.
组织特异性
Ubiquitously expressed.
相似性
Belongs to the DEAD box helicase family. eIF4A subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
功能
ATP-dependent RNA helicase. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Constitutes at least part of the platform anchoring other EJC proteins to spliced mRNAs. Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH/RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH/RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed.
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