Netrin G2 Rabbit pAb (一抗) | Bioss

bs-11103R

宠物抗体、农牧业/家禽抗体

Netrin G2 Rabbit pAb

轴突生长诱向因子G2/神经突起生长导向因子G2抗体

LHLL9381; Lmnt2; NEDBASH; NTNG1; NetrinG2; bA479K20.1; 2610016D08Rik; NTNG2_HUMAN; NTNG2; Laminet-2; KIAA1857; NTNG2_MOUSE; netrin G2; netrin G1; Netrin-G2

Rabbit

KLH conjugated synthetic peptide derived from human Netrin G2: 151-250/530

IgG

Liquid

affinity purified by Protein A

Polyclonal

56 kDa

62,50 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNC-6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient.