KLHL21 Rabbit pAb (一抗) | Bioss
货号：bs-8048R
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概述
产品编号
bs-8048R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
KLHL21 Rabbit pAb
中文名称
Kelch样蛋白21抗体
英文别名
1810045K06Rik; D330008A20; mKIAA0469; RGD1305863; KLH21_BOVIN; KLHL21; KLH21_HUMAN; KIAA0469; KLH21_MOUSE; KLH21_RAT; kelch like family member 21; kelch-like 21 (Drosophila)
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human KLHL21: 51-110/597
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
67 kDa
检测分子量
86 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Rabbit, Sheep, Cow, Dog | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human, Rat, Rabbit, Sheep, Cow, Dog)
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靶标
基因名
KLHL21
蛋白名
Kelch-like protein 21
亚基
Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.
亚细胞定位
Cytoplasm > cytoskeleton > spindle. Localizes to the spindle midzone and targets CUL3 to this region.
相似性
Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.
功能
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
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