CXCR1 Rabbit pAb (一抗) | Bioss
货号：bs-1009R
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常见问题
概述
产品编号
bs-1009R
英文名称
CXCR1 Rabbit pAb
中文名称
细胞表面趋化因子受体1抗体
英文别名
C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA; IL-8R A; CXCR1_HUMAN; CXCR1; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A (IL-8R A); IL-8 receptor type 1; CXCR1_MOUSE; CXCR1_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CXCR1: 186-280/350 <Cytoplasmic>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
40 kDa
检测分子量
61 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CXCR1主要表达于浸润的炎性细胞和肠上皮细胞表面.
背景资料
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Rabbit | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Rabbit)
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靶标
基因名
CXCR1
蛋白名
C-X-C chemokine receptor type 1
亚细胞定位
Cell membrane.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
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