Recombinant human TPO protein (Active, CHO) (重组蛋白) | Bioss

Recombinant human TPO protein (Active, CHO) (重组蛋白) | Bioss
货号:bs-48132P
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概述

产品编号
bs-48132P
产品类型
活性细胞因子
英文名称
Recombinant human TPO protein (Active, CHO)
中文名称
重组人促血小板生成素
英文别名
rHuThrombopoietin/TPO; TPO;
性状
Lyophilized
纯化方法
AC
理论分子量
35.4
储存液
PBS, 5% Mannitol and 0.01% Tween 80, pH7.4
SWISS
活性
Yes
序列
22-195/353
物种
Human
标签
Tag free
纯度
≥ 95% as determined by SDS-PAGE.
内毒素
≤10 EU/mg
表达系统
CHO cell
复溶
It is recommended to redissolve in sterile deionized water
保存条件
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 36 months at -20℃ to -80℃ in lyophilized state. 6 months at -20℃ to -80℃ under sterile conditions after reconstitution. 7-10 days at 2℃ to 49℃ under sterile conditions after reconstitution.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
重组人促血小板生成素-bs-48132P重组人促血小板生成素-bs-48132P

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靶标

基因名
THPO
蛋白名
Thrombopoietin
亚基
Interacts with DUOX1, DUOX2 and CYBA.
亚细胞定位
Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface.
疾病
Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the peroxidase family. XPO subfamily.
Contains 1 EGF-like domain.
Contains 1 Sushi (CCP/SCR) domain.
功能
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

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