Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase.SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human
1:1000-5000
IHC-P
Human
1:200-800
IHC-F
Human
1:200-800
IF
Human
1:200-800
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
SERPINB3
蛋白名
Serpin B3
亚细胞定位
Cytoplasm. Seems to also be secreted in plasma by cancerous cells but at a low level.
组织特异性
Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).
相似性
Belongs to the serpin family. Ov-serpin subfamily.
功能
May act as a protease inhibitor to modulate the host immune response against tumor cells.