CD47 Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-63335R

重组兔单抗

CD47 Recombinant Rabbit mAb

整合素相关蛋白CD47重组兔单抗

IAP; MER6; OA3; CD47_HUMAN; CD47; Antigenic surface determinant protein OA3; Integrin-associated protein (IAP); Protein MER6; CD47 molecule; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); antigen identified by monoclonal antibody 1D8; integrin associated protein; Rh-related antigen; leukocyte surface antigen CD47; CD47 glycoprotein

Rabbit

KLH conjugated synthetic peptide derived from human CD47

IgG

Liquid

affinity purified by Protein A

Recombinant

1F1

33 kDa

50 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

CD47

Leukocyte surface antigen CD47

Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.

Cell membrane; Multi-pass membrane protein.

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.