Recombinant human LR3 IGF1 protein (Active, CHO) (重组蛋白) | Bioss
货号：bs-48067P
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概述
产品编号
bs-48067P
产品类型
活性细胞因子
英文名称
Recombinant human LR3 IGF1 protein (Active, CHO)
中文名称
重组人LR3胰岛素样生长因子1
英文别名
Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1;
性状
Lyophilized
纯化方法
AC
理论分子量
9
储存液
Lyophilized from a 0.22μm-filtered solution containing PBS, 5% Mannitol and 0.01% Tween 80, pH7.4
研究领域
Cancer > Growth factors > Insulin and insulin-like
Developmental Biology > Post embryonic development > Aging
Developmental Biology > Post embryonic development > Growth hormones
Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Growth factors and hormones ELISA kits
Signal Transduction > Growth Factors/Hormones > Insulin / Insulin-like
SWISS
Gene ID
活性
Yes
序列
MFPAMPLSSLFVN+Gly49-Ala118(E51R)
物种
Human
标签
Tag free
纯度
≥ 95% as determined by SDS-PAGE.
内毒素
≤10 EU/mg
表达系统
CHO cell
复溶
It is recommended to redissolve in sterile deionized water.
保存条件
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 36 months at -20℃ to -80℃ in lyophilized state. 6 months at -20℃ to -80℃ under sterile conditions after reconstitution. 7-10 days at 2℃ to 8℃ under sterile conditions after reconstitution.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
胰岛素样生长因子1(IGF-1)是一种生长调节激素，由肝分泌并入血液循环的中性多肽，具有调节生长和代谢、胰岛素样及促细胞分裂的活性，主要作用于成人。
背景资料
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
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靶标
基因名
IGF1
蛋白名
Insulin-like growth factor I
亚细胞定位
Secreted.
疾病
Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
相似性
Belongs to the insulin family.
功能
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.