Recombinant Human B2M Protein, C-His (重组蛋白) | Bioss

货号:bs-101661P
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概述

产品编号
bs-101661P
英文名称
Recombinant Human B2M Protein, C-His
英文别名
Beta-2-microglobulin; B2M
性状
Lyophilized
纯化方法
AC
理论分子量
14.54 kDa
储存液
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
SWISS
Gene ID
活性
Not tested
序列
1-119/119
物种
Human
标签
C-His
纯度
>90% as determined by SDS-PAGE.
表达系统
HEK293 cell
复溶
Reconstitute in sterile water for a stock solution.
保存条件
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
小鼠抗人β2微球蛋白在中枢神经系统感染、肿瘤及全身性自身免疫性疾病患者脑脊液中,会出现β2MG蛋白不同程度的增高。
背景资料
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].

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靶标

基因名
B2M
蛋白名
beta-2-microglobulin
亚基
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.
亚细胞定位
Secreted. Note=Detected in serum and urine.
翻译后修饰
Glycation of Ile-21 is observed in long-term hemodialysis patients.
疾病
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
相似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

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