CD274/PD-L1/B7-H1 rHuz IgG1κ mAb (Ref: Atezolizumab) (Biosimilar抗体) | Bioss

Cancer > Tumor biomarkers > Tumor antigens

Cancer > Tumor immunology > Tumor-associated antigens

Immunology > Cell Type Markers > CD > Non-lineage

Immunology > Immune System Diseases > Autoimmune

Signal Transduction > Antibodies > pd-l1

Entrez Gene : 29126 Human

Entrez Gene : 60533 Mouse

Entrez Gene : 499342 Rat

Omim : 605402 Human

SwissProt : Q9NZQ7 Human

SwissProt : Q9EP73 Mouse

Unigene : 521989 Human

Unigene : 245363 Mouse

Unigene : 228198 Rat

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]