Osteocalcin belongs to the osteocalcin/matrix Gla protein family and constitutes 1 to 2% of the total bone protein. It is a 49 amino acid single chain vitamin K dependent protein, made by osteoblasts, and is a major component of the noncollagenous bone matrix. Post translational modification by a vitamin K dependent carboxylase produces three gamma carboxyglutamic acid residues at positions 17, 21 and 24, giving it a high affinity for calcium. It also binds strongly to apatite.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
IHC-P
Human, Mouse, Rat
1:100-500
IHC-F
Human, Mouse, Rat
1:100-500
IF
Human, Mouse, Rat
1:100-500
ELISA
Human, Mouse, Rat
1:5000-10000
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
BGLAP
蛋白名
Osteocalcin
亚细胞定位
Secreted.
翻译后修饰
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
相似性
Belongs to the osteocalcin/matrix Gla protein family. Contains 1 Gla (gamma-carboxy-glutamate) domain.
功能
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.