MYF5 Rabbit pAb (一抗) | Bioss

bs-6936R

农牧业/家禽抗体

MYF5 Rabbit pAb

生肌决定因子Myf5抗体

EORVA; bHLHc2; B130010J22Rik; Myf-5; MYF5_HUMAN; MYF5; Class C basic helix-loop-helix protein 2 (bHLHc2); MYF5_MOUSE;

Rabbit

KLH conjugated synthetic peptide derived from human MYF5: 61-160/255

IgG

Liquid

affinity purified by Protein A

Polyclonal

28 kDa

28 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

yf5是MyoD基因家族的一员，该家族的共同结构特点是具有1个保守的中央蛋白基序(motif)，大小为80个氨基酸，称为碱性螺旋-环-螺旋(bHLH)，bHLH高度保守，其中Basic结构是HLH螺旋结构的延伸，也是这一家族蛋白与DNA相互作用的区域，而HLH螺旋结构则是与其他因子相互作用的位点，即调控的重要区域。
生肌决定因子(MyoD)基因家族控制着肌细胞的增殖和分化，与肌纤维的数量、大小有着密切的关系，因而对肉质和风味有非常重要的作用，MyoD基因家族可编码4种不同的转录因子，分别为MyoD(Myf3)、Myogenin(MyoG)、Myf5、Myf6或MRF4，它们各自或协同控制着骨骼肌生成方面的关键调节因子。

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.