eIF4E Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt,IP | Bioss

bsm-63259R

重组兔单抗、mIHC精品抗体

eIF4E Recombinant Rabbit mAb

真核翻译起始因子4E重组兔单抗

AUTS19; CBP; EIF4E1; EIF4EL1; EIF4F; eIF-4E; EG668879; Eif4e-ps; If4e; IF4E_HUMAN; EIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; IF4E_MOUSE; IF4E_RAT; eukaryotic translation initiation factor 4E

Rabbit

A synthesized peptide derived from human eIF4E: 150-217

IgG

Liquid

affinity purified by Protein A

Recombinant

1F2

25 kDa

27 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EIF4E是蛋白合成的一个主要调控因子，它表达量增加会促进多种肿瘤的生长的增值、分化，因此EIF4E是一种非常重要的抗癌药物靶标。

Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing.

EIF4E

Eukaryotic translation initiation factor 4E

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1 (By similarity). Interacts with Lassa virus Z protein. Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA.

Cytoplasm, P-body.

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.

Belongs to the eukaryotic initiation factor 4E family.

Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.