胚胎干细胞关键蛋白1重组兔单抗
Rrmab®兔单抗
货号：bsm-63240R
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概述
产品编号
bsm-63240R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
Oct-1 Recombinant Rabbit mAb
中文名称
胚胎干细胞关键蛋白1重组兔单抗
英文别名
OCT1; OTF1; Oct1Z; oct-1B; 2810482H01Rik; NF-A1; Oct-1; Otf-1; PO2F1_HUMAN; POU2F1; Octamer-binding protein 1 (Oct-1); Octamer-binding transcription factor 1 (OTF-1); PO2F1_MOUSE; PO2F1_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Oct 1: 1-120/743
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3C12
理论分子量
76 kDa
检测分子量
95 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| Flow-Cyt | Human | Mouse, Rat | 1:50-100 |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
POU2F1
蛋白名
POU domain, class 2, transcription factor 1
亚基
Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.
亚细胞定位
Nucleus.
组织特异性
Ubiquitous. Isoform 2 is lymphocyte-specific.
翻译后修饰
Phosphorylated by PRKDC.
相似性
Belongs to the POU transcription factor family. Class-2 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.
功能
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
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