蛋白聚糖Versican重组兔单抗
Rrmab®兔单抗
货号：bsm-63236R
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概述
产品编号
bsm-63236R
产品类型
重组兔单抗
英文名称
Versican Recombinant Rabbit mAb
中文名称
蛋白聚糖Versican重组兔单抗
英文别名
CSPG2; ERVR; GHAP; PG-M; WGN; WGN1; 5430420N07Rik; 9430051N09; DPEAAE; NG2; PG-M(V0); PG-M(V1); hdf; CSPG2_HUMAN; VCAN; Chondroitin sulfate proteoglycan core protein 2 (Chondroitin sulfate proteoglycan 2); Glial hyaluronate-binding protein (GHAP); Large fibroblast proteoglycan; CSPG2_MOUSE; CSPG2_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human VCAN: 3200-3280
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12F7
理论分子量
373 kDa
检测分子量
373 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
VCAN
蛋白名
Versican core protein
亚基
Interacts with FBLN1 (By similarity).
亚细胞定位
Secreted, extracellular space, extracellular matrix.
组织特异性
Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.
翻译后修饰
Phosphorylation sites are present in the extracellular medium.
疾病
Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN.
相似性
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 2 EGF-like domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain.
Contains 1 C-type lectin domain.
Contains 2 EGF-like domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain.
功能
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
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