phospho-MLKL (S358) Recombinant Rabbit mAb (一抗) - WB | Bioss
Rrmab?兔单抗
货号：bsm-63224R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bsm-63224R
产品类型
磷酸化抗体、重组兔单抗
英文名称
phospho-MLKL (S358) Recombinant Rabbit mAb
中文名称
磷酸化MLKL重组兔单抗
英文别名
MLKL (phospho-S358); p-MLKL; phospho-MLKL; MLKL (phospho-Ser358); hMLKL; 9130019I15Rik; MLKL_HUMAN; MLKL; MLKL_MOUSE;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human MLKL around the phosphorylation site of S358: QT-pS-MS
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
5B5
理论分子量
54 kDa
检测分子量
54 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 |
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
MLKL
蛋白名
Mixed lineage kinase domain-like protein
亚基
Homotrimer; forms homotrimers on necroptosis induction. Interacts with RIPK3; the interaction is direct. Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3. Within this complex, may play a role in the proper targeting of RIPK1/RIPK3 to its downstream effector PGAM5.
Subcellular Location : Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Post-translational modifications : Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
亚细胞定位
Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
翻译后修饰
Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
相似性
Belongs to the protein kinase superfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
同靶标产品
相关文献
提示: 发表研究结果有使用 bsm-63224R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。