干扰素诱导跨膜蛋白3重组兔单抗
Rrmab®兔单抗
货号：bsm-63221R
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概述
产品编号
bsm-63221R
产品类型
重组兔单抗
英文名称
Fragilis Recombinant Rabbit mAb
中文名称
干扰素诱导跨膜蛋白3重组兔单抗
英文别名
1-8U; DSPA2b; IP15; 1110004C05Rik; Cd225; Cdw217; Fgls; mil-1; rat8; IFM3_HUMAN; IFITM3; Dispanin subfamily A member 2b (DSPA2b); Interferon-inducible protein 1-8U; IFM3_MOUSE; Fragilis protein; Interferon-inducible protein 15; Mouse ifitm-like protein 1 (Mil-1); IFM3_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human IFITM3: 1-50/133
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12E9
理论分子量
15 kDa
检测分子量
15 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:100-200 | |
| IHC-F | Human | 1:100-200 | |
| IF | Human | 1:100-200 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
IFITM3
蛋白名
Interferon-induced transmembrane protein 3
亚基
Interacts with SPP1; the interaction reduces OPN expression. Interacts with ATP6V0B and CD81.
亚细胞定位
Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.
翻译后修饰
Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
Not glycosylated.
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.
Not glycosylated.
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.
相似性
Belongs to the CD225 family.
功能
IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication.
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