Fragilis Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss

bsm-63221R

重组兔单抗

Fragilis Recombinant Rabbit mAb

干扰素诱导跨膜蛋白3重组兔单抗

1-8U; DSPA2b; IP15; 1110004C05Rik; Cd225; Cdw217; Fgls; mil-1; rat8; IFM3_HUMAN; IFITM3; Dispanin subfamily A member 2b (DSPA2b); Interferon-inducible protein 1-8U; IFM3_MOUSE; Fragilis protein; Interferon-inducible protein 15; Mouse ifitm-like protein 1 (Mil-1); IFM3_RAT; interferon induced transmembrane protein 3; interferon induced transmembrane protein 3 (1-8U); dispanin subfamily A member 2b

Rabbit

A synthesized peptide derived from human IFITM3: 1-50/133

IgG

Liquid

affinity purified by Protein A

Recombinant

12E9

15 kDa

15 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IFITM3

Interferon-induced transmembrane protein 3

Interacts with SPP1; the interaction reduces OPN expression. Interacts with ATP6V0B and CD81.

Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
Not glycosylated.
Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiqutination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.

Belongs to the CD225 family.

IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication.