类固醇激素合成急性调节蛋白重组兔单抗
Rrmab®兔单抗
货号：bsm-63220R
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概述
产品编号
bsm-63220R
产品类型
重组兔单抗、mIHC精品抗体
英文名称
StAR Recombinant Rabbit mAb
中文名称
类固醇激素合成急性调节蛋白重组兔单抗
英文别名
STARD1; D8Ertd419e; STAR_HUMAN; STAR; START domain-containing protein 1 (StARD1); STAR_MOUSE; Luteinizing hormone-induced protein; STAR_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human STAR: 222-285/285
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
2F12
理论分子量
32 kDa
检测分子量
32 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins
Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism
Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers
Signal Transduction > Growth Factors/Hormones > Hormones
Signal Transduction > Metabolism > Mitochondrial
Signal Transduction > Protein Trafficking > Organelle Proteins
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
STAR
蛋白名
Steroidogenic acute regulatory protein, mitochondrial
亚基
May interact with TSPO.
亚细胞定位
Mitochondrion.
疾病
Defects in STAR are the cause of adrenal hyperplasia type 1 (AH1) [MIM:201710]. The most severe form of adrenal hyperplasia. It is a condition characterized by onset of profound adrenocortical insufficiency shortly after birth, hyperpigmentation reflecting increased production of pro-opiomelanocortin, elevated plasma rennin activity as a consequence of reduced aldosterone synthesis, and male pseudohermaphroditism resulting from deficient fetal testicular testosterone synthesis. Affected individuals are phenotypic females irrespective of gonadal sex, and frequently die in infancy if mineralocorticoid and glucocorticoid replacement are not instituted.
相似性
Contains 1 START domain.
功能
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
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