HP | Haptoglobin Recombinant Rabbit mAb (一抗) - WB | Bioss

bsm-63203R

重组兔单抗

HP | Haptoglobin Recombinant Rabbit mAb

结合珠蛋白/触珠蛋白重组兔单抗

BP; HP2ALPHA2; HPA1S; HP-1; preHP2; Ba1-647; HPT_HUMAN; HP; Zonulin; HPT_MOUSE; HPT_RAT; Liver regeneration-related protein LRRG173; haptoglobin

Rabbit

A synthesized peptide derived from human Haptoglobin: 390-406

IgG

Liquid

affinity purified by Protein A

Recombinant

5F3

45 kDa

43 kDa

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

haptoglobin是一种酸性糖蛋白,属α2唾液酸糖蛋白,主要由肝脏合成，也可在脂肪细胞、皮肤、脾、肌肉、肺内等合成。

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

HP

Haptoglobin

Tetramer of two alpha and two beta chains; disufide-linked. The Hemoglobin/haptoglobin complex is composed of a haptoglobin dimer bound to two hemoglobin alpha-beta dimers. Interacts with CD163.

Secreted.

Expressed by the liver and secreted in plasma.

Anhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions. Note=The disease is caused by mutations affecting the gene represented in this entry.

Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 2 Sushi (CCP/SCR) domains.

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.