eIF4E结合蛋白重组兔单抗

bsm-63191R

重组兔单抗

eIF4EBP1 Recombinant Rabbit mAb

eIF4E结合蛋白重组兔单抗

4E-BP1; 4EBP1; BP-1; PHAS-I; 4EBP1_HUMAN; EIF4EBP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1 (PHAS-I); 4EBP1_MOUSE; 4EBP1_RAT;

Rabbit

A synthesized peptide derived from human 4E BP1: 1-46

IgG

Liquid

affinity purified by Protein A

Recombinant

9F8

13 kDa

18 kDa

10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    4E-BP1是一种分子量为10-12kDa 的酸性蛋白，与eIF4G 竞争结合。4E-BPs 对 eIF4E 的结合是可逆的，并依赖于 4E-BP 的磷酸化状态。非磷酸化的4E-BP1 能与 eiF4E 牢固结合，而磷酸化的4E-BP1则不能。
而一些蛋白激酶Akt、 TOR、 MAPK、S6激酶和Cdc2是已知的能通过对35、45、69位的苏氨酸残基或64位的丝氨酸残基进行磷酸化而使4E-BP1丧失对eIF4E结合能力的激酶。然而，并非所有的磷酸化事件都能同样地阻断4EBP1-eIF4E的相互作用。

Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.