PTPN11 Recombinant Rabbit mAb (一抗) - WB,IP | Bioss
Rrmab?兔单抗
货号：bsm-63152R
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概述
产品编号
bsm-63152R
产品类型
重组兔单抗
英文名称
PTPN11 Recombinant Rabbit mAb
中文名称
蛋白酪氨酸磷酸酶2重组兔单抗
英文别名
BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; 2700084A17Rik; PTP1D; SAP-2; SHP-2; Syp; PTN11_HUMAN; PTPN11; Protein-tyrosine phosphatase 1D (PTP-1D); Protein-tyrosine phosphatase 2C (PTP-2C); SH-PTP2 (SHP-2 | Shp2); 3.1.3.48; SHPTP2; PTN11_MOUSE; Protein-tyrosine phosphatase SYP; PTN11_RAT; protein tyrosine phosphatase non-receptor type 11; Noonan syndrome 1; protein tyrosine phosphatase, non-receptor type 11; SH2 domain-containing protein tyrosine phosphatase 2
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human SHP2: 8-39
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1C8
理论分子量
68 kDa
检测分子量
68 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
激酶和磷酸酶（Kinases and Phosphatases）
SHP2(SH-PTP2)参与多种细胞内信号传导 如MAP kinase、 PI3k等途径，SHP2也是许多其他原癌基因信号通路的重要组成部分，在细胞的增殖及分化等过程扮演重要的角色.
SHP2(SH-PTP2)参与多种细胞内信号传导 如MAP kinase、 PI3k等途径，SHP2也是许多其他原癌基因信号通路的重要组成部分，在细胞的增殖及分化等过程扮演重要的角色.
背景资料
SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
PTPN11
蛋白名
Tyrosine-protein phosphatase non-receptor type 11
亚基
Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1. Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity.
亚细胞定位
Cytoplasm.
组织特异性
Widely expressed, with highest levels in heart, brain, and skeletal muscle.
翻译后修饰
Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
疾病
Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
相似性
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.
功能
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
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