基质金属蛋白酶-1重组兔单抗
Rrmab®兔单抗
货号：bsm-63120R
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概述
产品编号
bsm-63120R
产品类型
重组兔单抗
英文名称
MMP1 Recombinant Rabbit mAb
中文名称
基质金属蛋白酶-1重组兔单抗
英文别名
CLG; CLGN; MMP-13; Mmp1; Mmp1a; MMP-1; MMP1_BOVIN; Fibroblast collagenase; Matrix metalloproteinase-1 (MMP-1); 3.4.24.7; MMP1_HUMAN; MMP13_MOUSE; Mmp13; Matrix metalloproteinase-13 (MMP-13); 3.4.24.-; MMP1_PIG; MMP1_RABIT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human MMP1: 110-145
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9F8
理论分子量
54 kDa
检测分子量
54 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > MMPs
Cancer > Tumor biomarkers > Enzymes > MMPs
Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > MMP
Cardiovascular > Atherosclerosis > Thrombosis > Endothelial mediators/regulators
Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > MMPs
Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > MMP
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
基质金属蛋白酶(matrix metalloproteinases, MMPs)是一族依赖锌离子而降解各种细胞外基质的蛋白酶，亦称IV型胶原酶或称明胶酶A，其主要功能为降解IV型胶原，因而它在肿瘤细胞突破基底膜屏障和浸润转移中起重要作用。
目前主要用于各种恶性肿瘤(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)中的基底膜检测与肿瘤转移浸润的研究。
背景资料
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse | 1:50-200 | |
| IHC-F | Human, Mouse | 1:50-200 | |
| IF | Human, Mouse | 1:50-200 | |
| Flow-Cyt | Human, Mouse | 1:50-100 | |
| ICC/IF | Human, Mouse | 1:50-200 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
MMP1
蛋白名
Interstitial collagenase
亚基
Interacts with HIV-1 Tat.
亚细胞定位
Secreted, extracellular space, extracellular matrix (Probable).
翻译后修饰
Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
相似性
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.
Contains 4 hemopexin-like domains.
功能
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
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