表皮生长因子受体3重组兔单抗
Rrmab®兔单抗
货号：bsm-63114R
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概述
产品编号
bsm-63114R
产品类型
重组兔单抗
英文名称
ErbB3 Recombinant Rabbit mAb
中文名称
表皮生长因子受体3重组兔单抗
英文别名
ErbB-3; FERLK; HER3; LCCS2; MDA-BF-1; VSCN1; c-erbB-3; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3; Erbb3r; nuc-ErbB3; ERBB3_HUMAN; ERBB3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; 2.7.10.1; ERBB3_MOUSE; Glial growth factor receptor; ERBB3_RAT;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human ErbB3: 1301-1342
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3F10
理论分子量
148 kDa
检测分子量
185 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Growth factors > EGF
Cancer > Oncoproteins/suppressors > Oncoproteins > Growth factor receptors
Cancer > Tumor biomarkers > Oncoproteins
Signal Transduction > Growth Factors/Hormones > EGF
Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases
Signal Transduction > Signaling Pathway > G Protein Signaling > Heterotrimeric G Proteins > G Proteins
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Binds and is activated by neuregulins and NTAK.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IP | Human, Mouse, Rat | 1:20-50 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
ERBB3
蛋白名
Receptor tyrosine-protein kinase erbB-3
亚基
Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7 and MUC1.
亚细胞定位
Isoform 1: Cell membrane; Single-pass type I. membrane protein. Isoform 2: Secreted.
组织特异性
Epithelial tissues and brain.
翻译后修饰
Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. Subject to autophosphorylation.
疾病
Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
Binds and is activated by neuregulins and NTAK.
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